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The Role of Mediator in Maintaining and Differentiating Human Mesenchymal Stem Cells

Description :  

The objective of the investigators of this research, in collaboration with Tulane University, is to examine a multi-subunit protein complex known as Mediator, which functions to retain the pluripotency of mesenchymal stem cells (MSCs). Specifically, through an understanding of the Mediator complex and its role in proper gene expression, the ultimate goal of characterizing MSCs for clinical use may be accomplished. In order to determine the role of Mediator, the investigators propose to identify the effects on MSCs following specific subunit loss and MSC-specific transcription factor loss in Mediator, and evaluate the impact on gene expression when Mediator is disrupted. Information derived from this study in relation to proper MSC gene regulation may enhance the therapeutic potential of MSCs in treating a variety of diseases and disorders.


Principal Investigator:  Newman, Jamie  --  Biological Sciences
Collaborators:  
Funding Agencies:  BoR thru LSU
Amount Awarded:  19,000

Start Period:  05/26/2014 End Period:  10/31/2014
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December 15th, 2017

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