Sustained Release of Minerals Using Degradable Hydrogels for the Repair of Bone Density
Bone loss associated with human spaceflight poses a challenge to aeronautical advancements including the possibility of long term life in space. For example, a 3-4 month space trip requires approximately 2-3 years to restore lost bone density. The researchers propose to develop a method of combating bone loss in space through slow calcium release by degradable hydrogels. It has previously been demonstrated that biocompatible hydrogels can be tailored to release pre-loaded drugs slowly. Conditions in the body can be used as triggers for hydrogel degradation and drug release. This project may find an ideal diffusion rate for sustained slow release of drugs. To battle calcium deficiency, drugs may be released in the desired amounts by changing pore size, crosslinking density, or the presence of nanofeatures. Upon the establishment of a hydrogel composition that swells, diffuses, and degrades at a predictable rate, a subcutaneous film may be developed for required calcium release, thereby compensating for the effects of low gravity environments.
Principal Investigator: Moore, Mary Caldorera -- Biomedical Engineering, Engineering and Technology Management, CBERS, Molecular Science and Nanotechnology
|Start Period: 08/08/2014
||End Period: 04/08/2015