Cardiomyocyte Generation for Cardiac Muscle Repair
Prolonged exposure to low-gravity environments poses a serious health risk to astronauts. One negative physical consequence is the weakening of cardiac muscle resulting from a decrease in the workload required to pump blood through the circulatory system. In light of limited cardiac tissue regeneration capacity, this project may explore repair methods that do not require a total heart transplant. The objective of the researchers of this project is to grow cardiomyocytes on a biocompatible substrate that may be used as an implant to restore damaged cardiac tissue. The investigators will utilize murine embryonic stem cells (mESCs) as a preliminary model for human cells. It is proposed that optimization of cell culture conditions may increase successful cardiomyocyte generation. The investigators will then extract RNA to determine genetic expression profiles and verify differentiation. The results of this project may, therefore, benefit the health of astronauts and NASA’s long term goal of space colony establishment.
Principal Investigator: Newman, Jamie -- Biological Sciences
|Start Period: 08/08/2014
||End Period: 04/08/2015