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Tailor-Made Variants of Site-Specific Recombinases as Tools for Genome Engineering

Description :  

The objective of the investigator of this research is to develop an efficient and universal genome manipulation technology through tailor-made variants of the site-specific recombinase Flp. This may be accomplished through: identifying and classifying all human genome sequences resembling the Flp target, known as FRT, evolving Flp variants capable of recombining with FRT-like sequences, and developing a selection method to be used in identifying successful site-specific recombination. This research may also include the correction of disease-causing mutations in model cell lines representing sickle cell disease, cystic fibrosis, Tay-Sachs syndrome, and Lesch-Nyhan syndrome by targeting FRT-like sites within the mutations, ultimately replacing the mutations in the cell lines. 

Principal Investigator:  Voziyanov, Yuri  --  Biological Sciences
Funding Agencies:  NIH
Amount Awarded:  1,238,896

Start Period:  08/01/2008 End Period:  05/31/2014
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November 16th, 2018

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