Effects of Spatially Distributed Nitric Oxide on Platelet Adhesion
Despite innovations in arterial stent technology, including the development of drug-eluting stents, stent failure due to thrombus formation continues to affect patients suffering from atherosclerosis and other cardiovascular issues. The objective of the investigators of this research is to examine spatial and temporal relationships between platelet activators, including ADP and collagen, and inhibitors, such as Nitric Oxide which contribute to thrombus formation at multiple sites. Through collaborations between Louisiana Tech University and LSU Health Sciences Center-Shreveport, the investigators propose to conduct in vitro microchannel studies of platelet adhesion in order to examine: the effect of thrombogeneic region size and perfusion time, the effect of shear rate, and the cross-interaction between thrombogenic regions separated by non-thrombogenic regions. These studies may reveal the mechanisms of positive and negative feedback contributing to thrombus formation, potentially facilitating the enhancement of stent design and atherosclerosis assessment.
Principal Investigator: Jones, Steven -- Biomedical Engineering
|Start Period: 07/01/2014
||End Period: 06/30/2015