Pre-Clinical Development of a Multi-Wavelength Pulse Photometer
The objective of the investigators of this research is to apply a pulse photometer system known as the NanoTracker in broad-based preclinical and clinical applications of gold nanoshells and nanaorods in the intravenous delivery and control of nanoparticles into tumors. In conjunction with this objective, the investigators also aim to develop a pharmacokinetic transport model for utilization in mathematical predictions of accumulations of doses and injection patterns. These objectives may be met through the implementation of the NanoTracker in currently utilized therapeutic agents and sensing/imaging compounds and an Intermediate Animal Model combined with data collection in existing clinical trials. These steps may facilitate the development of a pre-manufacturing prototype, which would function in similar fashion to multi-wavelength pulse oximeters and allow for more efficient nanoparticle delivery in diagnosing and treating multiple forms of solid cancers.
Principal Investigator: O'Neal, Patrick -- Biomedical Engineering
|Start Period: 06/01/2013
||End Period: 06/30/2015