Computational Model and Experimental Verification for the Development of Drug-Eluting Stent Coatings for Arterial Pharmacokinetics
The treatment of arterial stenosis, which can lead to cardiovascular damage and other side-effects, often involves the placement of a stent within the blocked vessel. One variation of traditional metal stents gaining in clinical popularity are Drug-Eluting Stents (DES), which allows for the sustained release of drugs capable of preventing restinosis in the affected vessel. While DES are useful, it is unknown how drug release is affected by factors including drug polarity, drug load and protein binding influences. It is the objective of the researchers of this project to develop three-dimensional models and experimental verification in actual stents. Collaborations between Louisiana Tech University and LSUHSC-Shreveport will facilitate characterizing drug kinetics and partitioning within arteries and may ultimately lead to more effective utilization of DES in treating arterial stenosis.
Principal Investigator: Dai, Weizhong -- Math & Statistics
|Start Period: 01/01/2013
||End Period: 01/31/2014