LBL Nanocarriers for Highly Efficient Solubilization of Insoluble Drug
Current methods of drug delivery, particularly intravenous administration of low-soluble drugs, are plagued with a number of issues including poor blood circulation, biodegradation, uncontrolled release rates and capillary embolization. The researchers of this proposed project seek to enhance drug delivery through the process of layer-by-layer (Lbl) polyelectrolyte shell nanoassembly. By manipulating the assembly of polycations and polyanions, the investigators will form multilayer shells around low-soluble drugs which could alleviate many of the issues affecting drug delivery. Through the production of stable nanocolloids, the investigators purpose to investigate cytoxicity, cellular interactions and uptake of drugs in mice. It is the researcher`s objective that a platform for stable drug delivery with high carrying capacities will expand the limited number of drugs used to treat cancer and other health issues.
Principal Investigator: Lvov, Yuri -- Chemistry
|Start Period: 01/11/2010
||End Period: 12/31/2014