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Nanoenhanced Bone Cement with Sustained Releases and Enhanced Material

Description :  

As national rates of orthopedic surgeries, orthopedic repairs, and dental procedures have seen dramatic increases in recent years, so has the need for enhanced bone cements, which is a prominent material being used in such procedures. Poly (methyl methacrylate) or (PMMA), is a type of standard bone cement product that has been used for decades, yet it has its limitations and risks. Current utilization of PMMA requires component mixture and preparation at high temperatures, which can lead to tissue damage upon application and limits the number of antibiotics that can be incorporated into the mixture. Due to the risk of infection associated with medical procedures requiring the use of PMMA, this project seeks to enhance the capabilities of PMMA using Halloysite Nanotubes (HNTs), which are natural, abundant clay nanotubes found in mineral deposits. By incorporating HNTs into PMMA, the properties of the cement can be greatly enhanced, show increased strength and durability, allow for greater selection of antimicrobial agents, and reduce the risk of infection and failure in medical procedures requiring bone cement. The goal of the proposed funding is to support prototype development, testing, and validation in an experimental osteomyelitis experimental animal model.


Principal Investigator:  Mills, David  --  Biological Sciences
Collaborators:  
Funding Agencies:  BoR
Amount Awarded:  19,875

Start Period:  01/01/2014 End Period:  12/31/2014
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