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2D and 3D Systems for Evaluating Potential Glutamate Involvement in TBI

Description :  A common injury seen in soldiers returning from battle is TBI, or traumatic brain injuries, which are associated with the negative phase of pressure waves from weapon blasts, and can result in nervous tissue death and/or impaired nervous function. Efforts to treat and examine the cellular impacts of these injuries are impaired by the lack of adequate imaging technology capable of analyzing site-specific locations. The goal of this project is to develop the technology required to achieve site-specific analysis of TBI. In a 3-year timeline, the investigators will (1) develop 3-D optical monitoring techniques to evaluate neuron cluster processing under blast pressure loading, (2) evaluate blast effects on co-culture systems including neurons and glial cells for more realistic in-vitro models of the brain, and (3) develop a multi-scale cellular analysis and simulation tool in 3-D that would allow for the prediction of blast impact effects that are then translated into neuronal injury. By focusing on cellular metabolic changes in the concentrations of glutamate and calcium ions, the tools and procedures to be developed will allow microscopic evaluations in those sufferin
Principal Investigator:  DeCoster, Mark  --  Biomedical Engineering
Collaborators:  Lvov, Y., Hegab, H., DeVries, George H., etc.
Funding Agencies:  US Army Research Lab
Amount Awarded:  39,100

Start Period:  11/26/2013 End Period:  11/25/2016
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November 15th, 2018

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