Description :  This project will extend the operational lifetime of a genetic monitoring system that has significant potential for use in space. While microfluidic technologies have characteristic features (compact size, integrated controls, low power and reagent consumption, etc.) that are ideal for extended space missions, their mediocre biocompatibility limits the achievable duration of continuous biological testing. This is caused by reagent buildup in the instrument due to the adsorption of biomolecules within the microfluidic channel. This current work will focus on reducing the reagent adsorption that occurs in a continuous-flow microscale PCR and DNA analysis device. Silane passivation treatments will be used to enhance the biocompatibility of the system. By eliminating reagent adsorption, this genetic monitoring system will be able to operate continuously during space flight, and thereby evaluate the effects of elevated radiation levels (both GCR and SPE) on human DNA.

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Principal Investigator:  Crews, Niel  --  Institute for Micromanufacturing

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Collaborators:  

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Funding Agencies:  NASA/LaSPACE

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Amount Awarded:  $12,088

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Start Period:  00/00/0000

End Period:  00/00/0000